Enfamil Optimum (Enspire), Our Closest Formula to Breast Milk, Immune-Supporting Lactoferrin and Brain-Supporting DHA Baby Formula, Powder 30 Oz Refill


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  • OUR CLOSEST FORMULA TO BREAST MILK: Enspire Optimum is Enfamil’s closest formula to breast milk with lactoferrin, found in colostrum + breast milk, and Dual HMOs
  • PROTEIN YOUR BABY NEEDS: Enspire Optimum has lactoferrin; an important protein in breast milk + colostrum that aids in iron absorption and supports baby’s immune system
  • EXCLUSIVE HuMO6 IMMUNE BLEND: Formula designed from breast milk with key components, such as 2’-FL HMO, LNnT HMO, Vitamin C, Vitamin E, Zinc, and Selenium
  • PEACE OF MIND: Enspire Optimum has NO artificial growth hormones, NO artificial colors or flavors, and NON-GMO, designed for complete nutrition for babies through 12 months
  • TRUSTED BY PARENTS & PEDIATRICIANS*: Enfamil is the #1 Trusted Infant Formula Brand By Pediatricians* & Parents and the #1 Trusted Brand for Brain-Building & Immune Support.
  • SNAP ELIGIBLE: Eligible to be purchased with Supplemental Nutrition Assistance Program (SNAP) benefits
  • SUBSCRIBE & SAVE: Choose Subscribe and Save for additional savings and convenience.
Brand Enfamil
Size 1.87 Pound (Pack of 1)
Item Weight 1.9 Pounds
Allergen Information Non-GMO
Item Form Powder

"Give your baby a great start with Enfamil Optimum—our most advanced formula designed to support immune health and brain development, inspired by the composition of breast milk. Enfamil Optimum, formerly known as Enfamil Enspire Optimum, is our closest baby formula to breast milk. It has lactoferrin, a key immune-supporting protein also found in colostrum and breast milk. It also has a dual HMO blend—2'-FL and LnNT—two of the most abundant human milk oligosaccharides (HMOs) naturally found in breast milk, to help nourish your baby’s immune system. It has brain-building DHA and is made without artificial growth hormones*, artificial colors, or flavors, Enfamil Optimum is a non-GMO† option for parents seeking premium infant nutrition through 12 months of age. Whether you're combo feeding or transitioning from breastfeeding, this formula offers both peace of mind and convenience for growing families. Join Enfamil Family Beginnings® to earn rewards with every purchase and access exclusive benefits and support. SNAP eligible."

  • bartholome.shanahan@yahoo.com

    08-03-2026

    We use this formula from birth, baby likes it and the price here especially with baby rigister discount is great!It says immune added, Hope it protect newborn and little baby

  • reanna.moore@lesch.org

    08-03-2026

    Let me start by saying this formula is likely not the "best tasting" one out there. "Best tasting" when it comes to food is often the worst when it comes to nutrition. If you're concerned about taste/smell this formula is probably not for you. I personally am un-bothered by the smell and only read the nutritional label when making my choice. If you're concerned about the quality of ingredients, don't want an obese child, and want to give your kid the best nutritional formula the US has to offer.... This product is for you.Secondly, I highly recommend ordering the refill packs on Amazon. Get your initial plastic tub from the grocery store then refill it the $55 box from Amazon. It's cheaper and you don't have to worry about seals being broken.This stuff is expensive.... But it helped develop my thriving 10-month-old who is talking, laughing, smiling, communicating, and hitting all of her physical milestones with ease. She was born 5 weeks early and we worried about her mental development. She was tiny and behind other babies at first in her milestones. Since my wife breastfed and could never keep up, this was initially recommended by our pediatrician to help supplement and eventually transition from breast milk. The lactoferrin and MFGM are the special ingredients along with lactose being it's only sweetener instead of corn syrup. The MFGM makes a big difference in mental development while the lactoferrin helps develop a healthy gut (which attributes to the loads of parents saying this is the only thing their little ones can keep down). These are the only two ingredients that set it apart from traditional formulas... and they truly make a world of difference. This stuff is great. If it is just a little too expensive check out Enfamil NeuroPro... Which is basically the same thing just minus the Lactoferrin (it still contains the brain developing MFGM). Hopefully next time our next child decides to stay in the belly full-term, the breastfeeding starts off on the right foot and continues through one year. If not, I won't think twice before using Enfamil Enspire again. It's truly a no-brainer and we are so grateful to Enfamil for developing this incredible formula.

  • mariaoesandraun4054@gmail.com

    08-03-2026

    We’ve been using Enfamil Optimum for our baby and it’s been working really well. No issues with gas, spit-up, or tummy discomfort — which was a huge relief finding our go to formula on the first try.It mixes smoothly (no weird clumps), and our baby took to the taste without any fuss. It also seems to keep them full and content between feedings.Honestly, it’s just been a great fit for us. Peace of mind knowing baby is getting good nutrition and it agrees with their system. Definitely recommend trying it if you’re looking for a quality formula that’s easy on sensitive tummies.

  • pdouglas@crist.biz

    08-03-2026

    This is a great value and the best price I can find for Enfamil Optimum on the market. The quality is consistent. My son loves the taste. He has been enjoying it since borned. Very happy with this formula.

  • reinaldoanemareinaldo@gmail.com

    08-03-2026

    Best baby formula in my opinion. We tried the regular gold enfamil too which was fine but wanted mroe good stuff so thats why we changed... i think its worth the extra cost. do subscribe and save to get a few bucks cheaper then usual since you will be using it anyway. glad to be using this!

  • sheilajosephine@yourdomain.com

    08-03-2026

    Great milk for my 2 boys. Zero issues with over gassing compared to the yellow.Easy mix and dissolves quickly.So far my boys have been growing healthy, smart and strong!

  • margaretsydeborahen5159@gmail.com

    08-03-2026

    My baby is 9 months old and has done amazing on this formula. No upset stomach. No constipation. No gas. She is a very easy baby. I think she’s trying to trick us into having baby #5 . I had one person basically tell me all formula was the same and it made no difference but then was really impressed by how strong and advanced my baby was. Idk I feel pretty good when I get proper nutrition. My baby was hardly sick WITH 3 school aged kids in the house. When she did get sick it was very short. She was able to fight it off quickly. I highly recommend this formula. Best wishes and congratulations on your new babies!!!

  • oabvshsidsjax738@gmail.com

    08-03-2026

    Both of my babies have thrived on this formula and done so well on it. We accidentally switched formulas from a Similac to this cold turkey on one of my babies (miscommunication with husband) and thankfully, he did just fine. No issues at all. Way more pricey than some formulas but I think its the worth the cost- especially if you wait for sales or use coupons.

There have been no reviews for this product yet.
  • bar******

    We use this formula from birth, baby likes it and the price here especially with baby rigister discount is great!It says immune added, Hope it protect newborn and little baby

  • rea******

    Let me start by saying this formula is likely not the "best tasting" one out there. "Best tasting" when it comes to food is often the worst when it comes to nutrition. If you're concerned about taste/smell this formula is probably not for you. I personally am un-bothered by the smell and only read the nutritional label when making my choice. If you're concerned about the quality of ingredients, don't want an obese child, and want to give your kid the best nutritional formula the US has to offer.... This product is for you.Secondly, I highly recommend ordering the refill packs on Amazon. Get your initial plastic tub from the grocery store then refill it the $55 box from Amazon. It's cheaper and you don't have to worry about seals being broken.This stuff is expensive.... But it helped develop my thriving 10-month-old who is talking, laughing, smiling, communicating, and hitting all of her physical milestones with ease. She was born 5 weeks early and we worried about her mental development. She was tiny and behind other babies at first in her milestones. Since my wife breastfed and could never keep up, this was initially recommended by our pediatrician to help supplement and eventually transition from breast milk. The lactoferrin and MFGM are the special ingredients along with lactose being it's only sweetener instead of corn syrup. The MFGM makes a big difference in mental development while the lactoferrin helps develop a healthy gut (which attributes to the loads of parents saying this is the only thing their little ones can keep down). These are the only two ingredients that set it apart from traditional formulas... and they truly make a world of difference. This stuff is great. If it is just a little too expensive check out Enfamil NeuroPro... Which is basically the same thing just minus the Lactoferrin (it still contains the brain developing MFGM). Hopefully next time our next child decides to stay in the belly full-term, the breastfeeding starts off on the right foot and continues through one year. If not, I won't think twice before using Enfamil Enspire again. It's truly a no-brainer and we are so grateful to Enfamil for developing this incredible formula.

  • mar******

    We’ve been using Enfamil Optimum for our baby and it’s been working really well. No issues with gas, spit-up, or tummy discomfort — which was a huge relief finding our go to formula on the first try.It mixes smoothly (no weird clumps), and our baby took to the taste without any fuss. It also seems to keep them full and content between feedings.Honestly, it’s just been a great fit for us. Peace of mind knowing baby is getting good nutrition and it agrees with their system. Definitely recommend trying it if you’re looking for a quality formula that’s easy on sensitive tummies.

  • pdo******

    This is a great value and the best price I can find for Enfamil Optimum on the market. The quality is consistent. My son loves the taste. He has been enjoying it since borned. Very happy with this formula.

  • rei******

    Best baby formula in my opinion. We tried the regular gold enfamil too which was fine but wanted mroe good stuff so thats why we changed... i think its worth the extra cost. do subscribe and save to get a few bucks cheaper then usual since you will be using it anyway. glad to be using this!

  • she******

    Great milk for my 2 boys. Zero issues with over gassing compared to the yellow.Easy mix and dissolves quickly.So far my boys have been growing healthy, smart and strong!

    Image

  • mar******

    My baby is 9 months old and has done amazing on this formula. No upset stomach. No constipation. No gas. She is a very easy baby. I think she’s trying to trick us into having baby #5 . I had one person basically tell me all formula was the same and it made no difference but then was really impressed by how strong and advanced my baby was. Idk I feel pretty good when I get proper nutrition. My baby was hardly sick WITH 3 school aged kids in the house. When she did get sick it was very short. She was able to fight it off quickly. I highly recommend this formula. Best wishes and congratulations on your new babies!!!

  • oab******

    Both of my babies have thrived on this formula and done so well on it. We accidentally switched formulas from a Similac to this cold turkey on one of my babies (miscommunication with husband) and thankfully, he did just fine. No issues at all. Way more pricey than some formulas but I think its the worth the cost- especially if you wait for sales or use coupons.

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